A powerful subset-based method identifies gene set associations and improves interpretation in UK Biobank

Tests of association between a phenotype and a set of genes in a biological pathway can provide insights into the genetic architecture of complex phenotypes beyond those obtained from single-variant or single-gene association analysis. However, most existing gene set tests have limited power to dete...

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Detaylı Bibliyografya
Yayımlandı:Am J Hum Genet
Asıl Yazarlar: Dutta, Diptavo, VandeHaar, Peter, Fritsche, Lars G., Zöllner, Sebastian, Boehnke, Michael, Scott, Laura J., Lee, Seunggeun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8059336/
https://ncbi.nlm.nih.gov/pubmed/33730541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2021.02.016
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