Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators

Pulmonary fibrosis (PF) can arise from unknown causes, as in idiopathic PF, or as a consequence of infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Current treatments for PF slow, but do not stop, disease progression. We report that treatment with a runt-related tr...

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Udgivet i:Am J Pathol
Main Authors: O'Hare, Michael, Amarnani, Dhanesh, Whitmore, Hannah A.B., An, Miranda, Marino, Claudia, Ramos, Leslie, Delgado-Tirado, Santiago, Hu, Xinyao, Chmielewska, Natalia, Chandrahas, Anita, Fitzek, Antonia, Heinrich, Fabian, Steurer, Stefan, Ondruschka, Benjamin, Glatzel, Markus, Krasemann, Susanne, Sepulveda-Falla, Diego, Lagares, David, Pedron, Julien, Bushweller, John H., Liu, Paul, Arboleda-Velasquez, Joseph F., Kim, Leo A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2021
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8059259/
https://ncbi.nlm.nih.gov/pubmed/33894177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2021.04.006
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