Optimized polyepitope neoantigen DNA vaccines elicit neoantigen-specific immune responses in preclinical models and in clinical translation

BACKGROUND: Preclinical studies and early clinical trials have shown that targeting cancer neoantigens is a promising approach towards the development of personalized cancer immunotherapies. DNA vaccines can be rapidly and efficiently manufactured and can integrate multiple neoantigens simultaneousl...

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Dades bibliogràfiques
Publicat a:Genome Med
Autors principals: Li, Lijin, Zhang, Xiuli, Wang, Xiaoli, Kim, Samuel W., Herndon, John M., Becker-Hapak, Michelle K., Carreno, Beatriz M., Myers, Nancy B., Sturmoski, Mark A., McLellan, Michael D., Miller, Christopher A., Johanns, Tanner M., Tan, Benjamin R., Dunn, Gavin P., Fleming, Timothy P., Hansen, Ted H., Goedegebuure, S. Peter, Gillanders, William E.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8059244/
https://ncbi.nlm.nih.gov/pubmed/33879241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-021-00872-4
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