Structural basis of TIR-domain assembly formation in MyD88/MAL-dependent TLR4 signaling

Toll-like receptor (TLR) signaling represents a key innate immune response to pathogen products. Recruitment of signaling adapters such as MAL/TIRAP and MyD88 to the receptors requires TIR-domain interactions, which remain structurally elusive. Here we show that MAL TIR domain spontaneously and reve...

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Udgivet i:Nat Struct Mol Biol
Main Authors: Ve, Thomas, Vajjhala, Parimala R., Hedger, Andrew, Croll, Tristan, DiMaio, Frank, Horsefield, Shane, Yu, Xiong, Lavrencic, Peter, Hassan, Zahid, Morgan, Garry P., Mansell, Ashley, Mobli, Mehdi, O’Carroll, Ailis, Chauvin, Brieuc, Gambin, Yann, Sierecki, Emma, Landsberg, Michael J., Stacey, Katryn J., Egelman, Edward H., Kobe, Bostjan
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8059215/
https://ncbi.nlm.nih.gov/pubmed/28759049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3444
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