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Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88
BACKGROUND: Higher-order self-assembly of proteins, or “prion-like” polymerisation, is now emerging as a simple and robust mechanism for signal amplification, in particular within the innate immune system, where the recognition of pathogens or danger-associated molecular patterns needs to trigger a...
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| Published in: | BMC Biol |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
BioMed Central
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6304784/ https://ncbi.nlm.nih.gov/pubmed/30583727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-018-0611-7 |
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