Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88

BACKGROUND: Higher-order self-assembly of proteins, or “prion-like” polymerisation, is now emerging as a simple and robust mechanism for signal amplification, in particular within the innate immune system, where the recognition of pathogens or danger-associated molecular patterns needs to trigger a...

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Dettagli Bibliografici
Pubblicato in:BMC Biol
Autori principali: O’Carroll, Ailís, Chauvin, Brieuc, Brown, James W. P., Meagher, Ava, Coyle, Joanne, Schill, Jurgen, Bhumkhar, Akshay, Hunter, Dominic J. B., Ve, Thomas, Kobe, Bostjan, Sierecki, Emma, Gambin, Yann
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6304784/
https://ncbi.nlm.nih.gov/pubmed/30583727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-018-0611-7
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