Th1 cytokine interferon gamma improves response in HER2 breast cancer by modulating the ubiquitin proteasomal pathway

HER2 breast cancer (BC) remains a significant problem in patients with locally advanced or metastatic BC. We investigated the relationship between T helper 1 (Th1) immune response and the proteasomal degradation pathway (PDP), in HER2-sensitive and -resistant cells. HER2 overexpression is partially...

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Publicado en:Mol Ther
Main Authors: Jia, Yongsheng, Kodumudi, Krithika N., Ramamoorthi, Ganesan, Basu, Amrita, Snyder, Colin, Wiener, Doris, Pilon-Thomas, Shari, Grover, Payal, Zhang, Hongtao, Greene, Mark I., Mo, Qianxing, Tong, Zhongsheng, Chen, Yong-Zi, Costa, Ricardo L.B., Han, Hyo, Lee, Catherine, Soliman, Hatem, Conejo-Garcia, Jose R., Koski, Gary, Czerniecki, Brian J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2021
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058490/
https://ncbi.nlm.nih.gov/pubmed/33412308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.12.037
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