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GDC-0575, a CHK1 Inhibitor, Impairs the Development of Colitis and Colitis-Associated Cancer by Inhibiting CCR2(+) Macrophage Infiltration in Mice
BACKGROUND: Checkpoint kinase 1 (CHK1) plays an important role in DNA damage response and cell cycle progression. Thus, targeting CHK1 is an efficient strategy for cancer therapy. PURPOSE: The present study aimed to investigate the potential therapeutic effects of GDC-0575, a CHK1-specific inhibitor...
Shranjeno v:
| izdano v: | Onco Targets Ther |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Dove
2021
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8058335/ https://ncbi.nlm.nih.gov/pubmed/33897258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S297132 |
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