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SH3BP4 promotes neuropilin-1 and α5-integrin endocytosis and is inhibited by Akt
Cells probe their surrounding matrix for attachment sites via integrins that are internalized by endocytosis. We find that SH3BP4 regulates integrin surface expression in a signaling dependent manner via clathrin coated pits (CCPs). Dephosphorylated SH3BP4 at S246 is efficiently recruited to CCPs, w...
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| Publicado no: | Dev Cell |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8058328/ https://ncbi.nlm.nih.gov/pubmed/33761321 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2021.03.009 |
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