Optimized photochemistry enables efficient analysis of dynamic RNA structuromes and interactomes in genetic and infectious diseases

Direct determination of RNA structures and interactions in living cells is critical for understanding their functions in normal physiology and disease states. Here, we present PARIS2, a dramatically improved method for RNA duplex determination in vivo with >4000-fold higher efficiency than previo...

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Publicat a:Nat Commun
Autors principals: Zhang, Minjie, Li, Kongpan, Bai, Jianhui, Velema, Willem A., Yu, Chengqing, van Damme, Ryan, Lee, Wilson H., Corpuz, Maia L., Chen, Jian-Fu, Lu, Zhipeng
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058046/
https://ncbi.nlm.nih.gov/pubmed/33879794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22552-y
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