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Water-Soluble Leaving Group Enables Hydrophobic Functionalization of RNA
Attachment of hydrophobic groups to RNA is challenging because of their poor aqueous solubility. One-step acylation of RNA 2′-OH groups in water using a water-soluble imidazole leaving group is described. The effect of the hydrophobic groups on hybridization is reported. Furthermore, propargyl-funct...
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| Veröffentlicht in: | Org Lett |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6478029/ https://ncbi.nlm.nih.gov/pubmed/30299958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.8b02938 |
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