Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis

Mammalian Hedgehog (HH) signalling pathway plays an essential role in tissue homeostasis and its deregulation is linked to rheumatological disorders. UBR5 is the mammalian homologue of the E3 ubiquitin-protein ligase Hyd, a negative regulator of the Hh-pathway in Drosophila. To investigate a possibl...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Mellis, David, Staines, Katherine A., Peluso, Silvia, Georgiou, Ioanna Ch., Dora, Natalie, Kubiak, Malgorzata, van’t Hof, Rob, Grillo, Michela, Farquharson, Colin, Kinsella, Elaine, Thornburn, Anna, Ralston, Stuart H., Salter, Donald M., Riobo-Del Galdo, Natalia A., Hill, Robert E., Ditzel, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8057592/
https://ncbi.nlm.nih.gov/pubmed/33819267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009275
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