IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation

BACKGROUND: Immunosuppressive and anti-cytokine treatment may have a protective effect for patients with COVID-19. Understanding the immune cell states shared between COVID-19 and other inflammatory diseases with established therapies may help nominate immunomodulatory therapies. METHODS: To identif...

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Bibliographic Details
Published in:Genome Med
Main Authors: Zhang, Fan, Mears, Joseph R., Shakib, Lorien, Beynor, Jessica I., Shanaj, Sara, Korsunsky, Ilya, Nathan, Aparna, Donlin, Laura T., Raychaudhuri, Soumya
Format: Artigo
Language:Inglês
Published: BioMed Central 2021
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8057009/
https://ncbi.nlm.nih.gov/pubmed/33879239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-021-00881-3
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