Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2

Two-pore channel 2 (TPC2) resides in endolysosomal membranes but also in lysosome-related organelles such as the melanin producing melanosomes. Gain-of-function polymorphisms in hTPC2 are associated with decreased melanin production and blond hair color. Vice versa genetic ablation of TPC2 increases...

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Publicado no:Sci Rep
Main Authors: Netcharoensirisuk, Ponsawan, Abrahamian, Carla, Tang, Rachel, Chen, Cheng-Chang, Rosato, Anna Scotto, Beyers, Wyatt, Chao, Yu-Kai, Filippini, Antonio, Di Pietro, Santiago, Bartel, Karin, Biel, Martin, Vollmar, Angelika M., Umehara, Kaoru, De-Eknamkul, Wanchai, Grimm, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8055690/
https://ncbi.nlm.nih.gov/pubmed/33875769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-88196-6
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