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Structure-mediated RNA decay by UPF1 and G3BP1

Post-transcriptional mechanisms regulate the stability and hence expression of coding and noncoding RNAs. Sequence-specific features within the 3’-untranslated region (3’UTR) often direct mRNAs for decay. Here we characterize a genome-wide RNA decay pathway that reduces the half-lives of mRNAs based...

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Publicat a:Mol Cell
Autors principals: Fischer, Joseph W., Busa, Veronica F., Shao, Yue, Leung, Anthony K. L.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8055448/
https://ncbi.nlm.nih.gov/pubmed/32017897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.01.021
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