Stress-Induced Transcriptional Memory Accelerates Promoter-Proximal Pause-Release and Decelerates Termination over Mitotic Divisions

Heat shock instantly reprograms transcription. Whether gene and enhancer transcription fully recover from stress, and whether stress establishes a memory by provoking transcription regulation that persists through mitosis, remained unknown. Here, we measured nascent transcription and chromatin acces...

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Udgivet i:Mol Cell
Main Authors: Vihervaara, Anniina, Mahat, Dig Bijay, Himanen, Samu V., Blom, Malin A.H., Lis, John T., Sistonen, Lea
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054823/
https://ncbi.nlm.nih.gov/pubmed/33784494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.03.007
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