Human challenge study with a Shigella bioconjugate vaccine: Analyses of clinical efficacy and correlate of protection

BACKGROUND: Shigellosis is a major cause of moderate to severe diarrhoea and dysentery in children under 5 years of age in low and middle-income countries. The Flexyn2a vaccine conjugates the O-polysaccharide of Shigella flexneri 2a to Pseudomonas aeruginosa exotoxin A. We describe a Phase 2b proof-...

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Bibliografski detalji
Izdano u:EBioMedicine
Glavni autori: Talaat, Kawsar R., Alaimo, Cristina, Martin, Patricia, Bourgeois, A. Louis, Dreyer, Anita M., Kaminski, Robert W., Porter, Chad K., Chakraborty, Subhra, Clarkson, Kristen A., Brubaker, Jessica, Elwood, Daniel, Frölich, Rahel, DeNearing, Barbara, Weerts, Hailey, Feijoo, Brittany L., Halpern, Jane, Sack, David, Riddle, Mark S., Fonck, Veronica Gambillara
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2021
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054157/
https://ncbi.nlm.nih.gov/pubmed/33862589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2021.103310
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