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Human challenge study with a Shigella bioconjugate vaccine: Analyses of clinical efficacy and correlate of protection

BACKGROUND: Shigellosis is a major cause of moderate to severe diarrhoea and dysentery in children under 5 years of age in low and middle-income countries. The Flexyn2a vaccine conjugates the O-polysaccharide of Shigella flexneri 2a to Pseudomonas aeruginosa exotoxin A. We describe a Phase 2b proof-...

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書誌詳細
出版年:EBioMedicine
主要な著者: Talaat, Kawsar R., Alaimo, Cristina, Martin, Patricia, Bourgeois, A. Louis, Dreyer, Anita M., Kaminski, Robert W., Porter, Chad K., Chakraborty, Subhra, Clarkson, Kristen A., Brubaker, Jessica, Elwood, Daniel, Frölich, Rahel, DeNearing, Barbara, Weerts, Hailey, Feijoo, Brittany L., Halpern, Jane, Sack, David, Riddle, Mark S., Fonck, Veronica Gambillara
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier 2021
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054157/
https://ncbi.nlm.nih.gov/pubmed/33862589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2021.103310
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