Clinical endpoints in the controlled human challenge model for Shigella: A call for standardization and the development of a disease severity score

BACKGROUND: Since 1946 the controlled human infection model (CHIM) for Shigella has been used to improve understanding of disease pathogenesis, describe clinical and immunologic responses to infection and as a tool for vaccine development. As the frequency and intent for use in vaccine comparisons i...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Porter, Chad K., Lynen, Amanda, Riddle, Mark S., Talaat, Kawsar, Sack, David, Gutiérrez, Ramiro L., McKenzie, Robin, DeNearing, Barbara, Feijoo, Brittany, Kaminski, Robert W., Taylor, David N., Kirkpatrick, Beth D., Bourgeois, A. Louis
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5874036/
https://ncbi.nlm.nih.gov/pubmed/29590182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0194325
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