Epigenetic reprogramming of tumor cell–intrinsic STING function sculpts antigenicity and T cell recognition of melanoma

Lack or loss of tumor antigenicity represents one of the key mechanisms of immune escape and resistance to T cell–based immunotherapies. Evidence suggests that activation of stimulator of interferon genes (STING) signaling in tumor cells can augment their antigenicity by triggering a type I IFN-medi...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Falahat, Rana, Berglund, Anders, Putney, Ryan M., Perez-Villarroel, Patricio, Aoyama, Shota, Pilon-Thomas, Shari, Barber, Glen N., Mulé, James J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2021
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8053941/
https://ncbi.nlm.nih.gov/pubmed/33827917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2013598118
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