GDC-0326 Enhances the Effects of 5-Fu in Colorectal Cancer Cells by Inducing Necroptotic Death

AIM: Chemoresistance to 5-fluorouracil (5-Fu) is common in colorectal cancer (CRC). Programmed necrosis (necroptosis) is an alternative form of programmed cell death regulated by receptor-interacting protein kinase (RIPK) 1 and 3, assumed as a novel target of cancer therapy. In this study, we aimed...

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Bibliographische Detailangaben
Veröffentlicht in:Onco Targets Ther
Hauptverfasser: Zhang, Zizhen, Ju, Fangyu, Chen, Fei, Wu, Haoyue, Chen, Jingyu, Zhong, Jing, Shao, Liming, Zheng, Sheng, Wang, Liangjing, Xue, Meng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove 2021
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8053532/
https://ncbi.nlm.nih.gov/pubmed/33880032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S302334
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