Induction of cytotoxic effector cells towards cholangiocellular, pancreatic, and colorectal tumor cells by activation of the immune checkpoint CD40/CD40L on dendritic cells

INTRODUCTION: Gastrointestinal (GI) malignancies, such as cholangiocarcinoma, pancreatic carcinoma, and metastatic colorectal carcinoma, have a poor prognosis and effective therapeutic approaches are still challenging. Checkpoint inhibition with PD-1 or PDL-1 antibodies revealed promising results in...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Immunother
Main Authors: Sadeghlar, Farsaneh, Vogt, Annabelle, Mohr, Raphael U., Mahn, Robert, van Beekum, Katrin, Kornek, Miroslaw, Weismüller, Tobias J., Branchi, Vittorio, Matthaei, Hanno, Toma, Marieta, Schmidt-Wolf, I. G. H., Kalff, Jörg C., Strassburg, Christian P., González-Carmona, Maria A.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8053193/
https://ncbi.nlm.nih.gov/pubmed/33180184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-020-02746-x
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