IL-15 superagonist N-803 improves IFNγ production and killing of leukemia and ovarian cancer cells by CD34(+) progenitor-derived NK cells

Allogeneic natural killer (NK) cell transfer is a potential immunotherapy to eliminate and control cancer. A promising source are CD34 + hematopoietic progenitor cells (HPCs), since large numbers of cytotoxic NK cells can be generated. Effective boosting of NK cell function can be achieved by interl...

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Udgivet i:Cancer Immunol Immunother
Main Authors: Van der Meer, J. M. R., Maas, R. J. A., Guldevall, K., Klarenaar, K., de Jonge, P. K. J. D., Evert, J. S. Hoogstad-van, van der Waart, A. B., Cany, J., Safrit, J. T., Lee, J. H., Wagena, E., Friedl, P., Önfelt, B., Massuger, L. F., Schaap, N. P. M., Jansen, J. H., Hobo, W., Dolstra, H.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2020
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8053152/
https://ncbi.nlm.nih.gov/pubmed/33140189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-020-02749-8
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