Discovery of a AHR pelargonidin agonist that counter-regulates Ace2 expression and attenuates ACE2-SARS-CoV-2 interaction

The severe acute respiratory syndrome (SARS)-CoV-2 is the pathogenetic agent of Corona Virus Induced Disease (COVID)19. The virus enters the human cells after binding to the angiotensin converting enzyme (ACE)2 receptor in target tissues. ACE2 expression is induced in response to inflammation. The c...

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Publicado no:Biochem Pharmacol
Main Authors: Biagioli, Michele, Marchianò, Silvia, Roselli, Rosalinda, Di Giorgio, Cristina, Bellini, Rachele, Bordoni, Martina, Gidari, Anna, Sabbatini, Samuele, Francisci, Daniela, Fiorillo, Bianca, Catalanotti, Bruno, Distrutti, Eleonora, Carino, Adriana, Zampella, Angela, Costantino, Gabriele, Fiorucci, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8052506/
https://ncbi.nlm.nih.gov/pubmed/33872570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2021.114564
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