Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes

Antibodies targeting the NANP/NVDP repeat domain of the Plasmodium falciparum circumsporozoite protein (CSP(Repeat)) can protect against malaria. However, it has also been suggested that the CSP(Repeat) is a decoy that prevents the immune system from mounting responses against other domains of CSP....

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Vydáno v:Cell Rep
Hlavní autoři: Chatterjee, Deepyan, Lewis, Fiona J., Sutton, Henry J., Kaczmarski, Joe A., Gao, Xin, Cai, Yeping, McNamara, Hayley A., Jackson, Colin J., Cockburn, Ian A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8052187/
https://ncbi.nlm.nih.gov/pubmed/33852850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108996
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