T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein

The repeat region of the Plasmodium falciparum circumsporozoite protein (CSP) is a major vaccine antigen because it can be targeted by parasite neutralizing antibodies; however, little is known about this interaction. We used isothermal titration calorimetry, X-ray crystallography and mutagenesis-va...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Fisher, Camilla R., Sutton, Henry J., Kaczmarski, Joe A., McNamara, Hayley A., Clifton, Ben, Mitchell, Joshua, Cai, Yeping, Dups, Johanna N., D'Arcy, Nicholas J., Singh, Mandeep, Chuah, Aaron, Peat, Thomas S., Jackson, Colin J., Cockburn, Ian A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552345/
https://ncbi.nlm.nih.gov/pubmed/28759640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006469
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