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Computer-Aided Drug Discovery Identifies Alkaloid Inhibitors of Parkinson's Disease Associated Protein, Prolyl Oligopeptidase

Parkinson's disease is a common neurodegenerative disorder marked by the accumulation of the protein alpha synuclein. Studies have indicated the role of prolyl oligopeptidase (POP), a serine protease, in alpha synuclein accumulation. Therefore, POP emerges as an attractive medicinal target. Tra...

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Detalhes bibliográficos
Publicado no:Evid Based Complement Alternat Med
Main Authors: Kulkarni, Apoorva M., Rampogu, Shailima, Lee, Keun Woo
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8052153/
https://ncbi.nlm.nih.gov/pubmed/33897801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/6687572
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