A cyclin D1-dependent transcriptional program predicts clinical outcome in mantle cell lymphoma

PURPOSE: Mantle cell lymphoma (MCL) is characterized by the t(11;14)(q13;q32) translocation leading to cyclin D1 overexpression. Cyclin D1 is a major cell cycle regulator and also regulates transcription, but the impact of cyclin D1-mediated transcriptional dysregulation on MCL pathogenesis remains...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Demajo, Santiago, Albero, Robert, Clot, Guillem, Castellano, Giancarlo, Navarro, Alba, Capdevila, Cristina, Enjuanes, Anna, Nadeu, Ferran, Giné, Eva, Pinyol, Magda, Jaffe, Elaine S., Ott, German, Staudt, Louis M., Rosenwald, Andreas, Scott, David W., Rimsza, Lisa M., López-Guillermo, Armando, Beà, Sílvia, Campo, Elias, Jares, Pedro
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8051616/
https://ncbi.nlm.nih.gov/pubmed/33046520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-2868
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