RRM2 silencing suppresses malignant phenotype and enhances radiosensitivity via activating cGAS/STING signaling pathway in lung adenocarcinoma

BACKGROUND: As one of the most common malignancy, lung adenocarcinoma (LUAD) is characterized by low 5-year survival rate. This research aimed to investigate the effects of ribonucleotide reductase regulatory subunit M2 (RRM2) on malignant biological behaviors and activation of cGAS/STING pathway. W...

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Bibliografski detalji
Izdano u:Cell Biosci
Glavni autori: Jiang, Xueping, Li, Yangyi, Zhang, Nannan, Gao, Yanping, Han, Linzhi, Li, Shuying, Li, Jiali, Liu, Xingyu, Gong, Yan, Xie, Conghua
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2021
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8051110/
https://ncbi.nlm.nih.gov/pubmed/33858512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-021-00586-5
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