Evidence for tmTNF reverse signaling in vivo: Implications for an arginase-1-mediated therapeutic effect of TNF inhibitors during inflammation

In order to ascertain the significance of transmembrane tumor necrosis factor (tmTNF) reverse signaling in vivo, we generated a triple transgenic mouse model (3TG, TNFR1−/−, TNFR2−/−, and tmTNFKI/KI) in which all canonical tumor necrosis factor (TNF) signaling was abolished. In bone-marrow-derived m...

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Veröffentlicht in:iScience
Hauptverfasser: Diallo, Katy, Simons, Numa, Sayegh, Souraya, Baron, Michel, Degboé, Yannick, Boyer, Jean-Frédéric, Kruglov, Andrey, Nedospasov, Sergei, Novarino, Julien, Aloulou, Meryem, Fazilleau, Nicolas, Constantin, Arnaud, Cantagrel, Alain, Davignon, Jean-Luc, Rauwel, Benjamin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050384/
https://ncbi.nlm.nih.gov/pubmed/33889824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102331
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