An in vitro tumorigenesis model based on live-cell-generated oxygen and nutrient gradients

The tumor microenvironment (TME) is multi-cellular, spatially heterogenous, and contains cell-generated gradients of soluble molecules. Current cell-based model systems lack this complexity or are difficult to interrogate microscopically. We present a 2D live-cell chamber that approximates the TME a...

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Udgivet i:Commun Biol
Main Authors: Gilmore, Anne C., Flaherty, Sarah J., Somasundaram, Veena, Scheiblin, David A., Lockett, Stephen J., Wink, David A., Heinz, William F.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050328/
https://ncbi.nlm.nih.gov/pubmed/33859337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01954-0
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