Tissue plasminogen activator is a ligand of cation-independent mannose 6-phosphate receptor and consists of glycoforms that contain mannose 6-phosphate

Plasmin is the key enzyme in fibrinolysis. Upon interaction with plasminogen activators, the zymogen plasminogen is converted to active plasmin. Some studies indicate plasminogen activation is regulated by cation-independent mannose 6-phosphate receptor (CI-MPR), a protein that facilitates lysosomal...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Miller, James J., Bohnsack, Richard N., Olson, Linda J., Ishihara, Mayumi, Aoki, Kazuhiro, Tiemeyer, Michael, Dahms, Nancy M.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050316/
https://ncbi.nlm.nih.gov/pubmed/33859256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-87579-z
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