Ceramide kinase regulates TNF-α-induced immune responses in human monocytic cells

Ceramide kinase (CERK) phosphorylates ceramide to produce ceramide-1-phosphate (C1P), which is involved in the development of metabolic inflammation. TNF-α modulates inflammatory responses in monocytes associated with various inflammatory disorders; however, the underlying mechanisms remain not full...

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Udgivet i:Sci Rep
Main Authors: Al-Rashed, Fatema, Ahmad, Zunair, Snider, Ashley J., Thomas, Reeby, Kochumon, Shihab, Melhem, Motasem, Sindhu, Sardar, Obeid, Lina M., Al-Mulla, Fahd, Hannun, Yusuf A., Ahmad, Rasheed
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050074/
https://ncbi.nlm.nih.gov/pubmed/33859296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-87795-7
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