Endogenous generation of nitro-fatty acid hybrids having dual nitrate ester (RONO(2)) and nitroalkene (RNO(2)) substituents

Organic nitrate esters, long-recognized therapies for cardiovascular disorders, have not been detected biologically. We characterize in rat stomach unsaturated fatty acid nitration reactions that proceed by generation of nitro-nitrate intermediates (NO(2)–ONO(2)-FA) via oxygen and nitrite dependent...

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Publicat a:Redox Biol
Autors principals: Fazzari, Marco, Woodcock, Steven R., Rowart, Pascal, Ricart, Karina, Lancaster, Jack R., Patel, Rakesh, Vitturi, Dario A., Freeman, Bruce A., Schopfer, Francisco J.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2021
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8049994/
https://ncbi.nlm.nih.gov/pubmed/33819836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2021.101913
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