Electrophilic fatty acid nitroalkenes are systemically transported and distributed upon esterification to complex lipids

Electrophilic nitro-fatty acids [NO(2)-FAs (fatty acid nitroalkenes)] showed beneficial signaling actions in preclinical studies and safety in phase 1 clinical trials. A detailed description of the pharmacokinetics (PK) of NO(2)-FAs is complicated by the capability of electrophilic fatty acids to al...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Fazzari, Marco, Vitturi, Dario A., Woodcock, Steven R., Salvatore, Sonia R., Freeman, Bruce A., Schopfer, Francisco J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358300/
https://ncbi.nlm.nih.gov/pubmed/30545956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M088815
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