Nondisplaceable Binding Is a Potential Confounding Factor in (11)C-PBR28 Translocator Protein PET Studies

The PET ligand (11)C-PBR28 (N-((2-(methoxy-(11)C)-phenyl)methyl)-N-(6-phenoxy-3-pyridinyl)acetamide) binds to the 18-kDa translocator protein (TSPO), a biomarker of glia. In clinical studies of TSPO, the ligand total distribution volume, V(T), is frequently the reported outcome measure. Since V(T) i...

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Bibliografske podrobnosti
izdano v:J Nucl Med
Main Authors: Laurell, Gjertrud L., Plavén-Sigray, Pontus, Jucaite, Aurelija, Varrone, Andrea, Cosgrove, Kelly P., Svarer, Claus, Knudsen, Gitte M., Ogden, R. Todd, Zanderigo, Francesca, Cervenka, Simon, Hillmer, Ansel T., Schain, Martin
Format: Artigo
Jezik:Inglês
Izdano: Society of Nuclear Medicine 2021
Teme:
Pulmonary
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8049343/
https://ncbi.nlm.nih.gov/pubmed/32680926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.120.243717
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