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Large‐Peptide Permeation Through a Membrane Channel: Understanding Protamine Translocation Through CymA from Klebsiella Oxytoca

Quantifying the passage of the large peptide protamine (Ptm) across CymA, a passive channel for cyclodextrin uptake, is in the focus of this study. Using a reporter‐pair‐based fluorescence membrane assay we detected the entry of Ptm into liposomes containing CymA. The kinetics of the Ptm entry was i...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Angew Chem Int Ed Engl
Hauptverfasser: Pangeni, Sushil, Prajapati, Jigneshkumar Dahyabhai, Bafna, Jayesh, Nilam, Mohamed, Nau, Werner M., Kleinekathöfer, Ulrich, Winterhalter, Mathias
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8049027/
https://ncbi.nlm.nih.gov/pubmed/33580541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202016943
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