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“NAD‐display”: Ultrahigh‐Throughput in Vitro Screening of NAD(H) Dehydrogenases Using Bead Display and Flow Cytometry

NAD(H)‐utiliing enzymes have been the subject of directed evolution campaigns to improve their function. To enable access to a larger swath of sequence space, we demonstrate the utility of a cell‐free, ultrahigh‐throughput directed evolution platform for dehydrogenases. Microbeads (1.5 million per s...

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Foilsithe in:Angew Chem Int Ed Engl
Main Authors: Lindenburg, Laurens, Hollfelder, Florian
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2021
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048591/
https://ncbi.nlm.nih.gov/pubmed/33470025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202013486
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