Lysophosphatidic acid (LPA)-antibody (504B3) engagement detected by interferometry identifies off-target binding

BACKGROUND: Lysophosphatidic acid (LPA) is a bioactive lysophospholipid that acts through its six cognate G protein-coupled receptors. As a family, lysophospholipids have already produced medicines (e.g., sphingosine 1-phosphate) as is being pursued for LPA through the use of specific antibodies tha...

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Bibliografiske detaljer
Udgivet i:Lipids Health Dis
Main Authors: Ray, Manisha, Kihara, Yasuyuki, Bornhop, Darryl J., Chun, Jerold
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Short Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048308/
https://ncbi.nlm.nih.gov/pubmed/33853612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12944-021-01454-4
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