Sulfated glycolipid PG545 induces endoplasmic reticulum stress and augments autophagic flux by enhancing anticancer chemotherapy efficacy in endometrial cancer

The sulfated glycolipid PG545 shows promising antitumor activity in various cancers. This study was conducted to explore the effects and the mechanism of PG545 action in endometrial cancer (EC). PG545 exhibited strong synergy as assessed by the Chou-Talalay-Method in vitro when combined with cisplat...

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Publicado no:Biochem Pharmacol
Main Authors: Hoffmann, Robert, Bhattacharya, Sayantani Sarkar, Roy, Debarshi, Winterhoff, Boris, Schmidmaier, Ralf, Dredge, Keith, Hammond, Edward, Shridhar, Viji
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048055/
https://ncbi.nlm.nih.gov/pubmed/32360360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2020.114003
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