Glutathione S-Transferase P Influences Redox Homeostasis and Response to Drugs that Induce the Unfolded Protein Response in Zebrafish

We have created a novel glutathione S-transferase π1 (gstp1) knockout (KO) zebrafish model and used it for comparative analyses of redox homeostasis and response to drugs that cause endoplasmic reticulum (ER) stress and induce the unfolded protein response (UPR). Under basal conditions, gstp1 KO lar...

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Vydáno v:J Pharmacol Exp Ther
Hlavní autoři: Zhang, Leilei, Kim, Seok-Hyung, Park, Ki-Hoon, Townsend, Danyelle M., Tew, Kenneth D., Zhi-wei, Ye, Jie, Zhang
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2021
Témata:
Cellular and Molecular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8047768/
https://ncbi.nlm.nih.gov/pubmed/33514607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.120.000417
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