The gut microbiome influences the bioavailability of olanzapine in rats

BACKGROUND: The role of the gut microbiome in the biotransformation of drugs has recently come under scrutiny. It remains unclear whether the gut microbiome directly influences the extent of drug absorbed after oral administration and thus potentially alters clinical pharmacokinetics. METHODS: In th...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Cussotto, Sofia, Walsh, Jacinta, Golubeva, Anna V., Zhdanov, Alexander V., Strain, Conall R., Fouhy, Fiona, Stanton, Catherine, Dinan, Timothy G., Hyland, Niall P., Clarke, Gerard, Cryan, John F., Griffin, Brendan T.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8047500/
https://ncbi.nlm.nih.gov/pubmed/33819741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2021.103307
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