MiR-22 Inhibition Alleviates Cardiac Dysfunction in Doxorubicin-Induced Cardiomyopathy by Targeting the sirt1/PGC-1α Pathway

Doxorubicin (DOX) cardiotoxicity is a life-threatening side effect that leads to a poor prognosis in patients receiving chemotherapy. We investigated the role of miR-22 in doxorubicin-induced cardiomyopathy and the underlying mechanism in vivo and in vitro. Specifically, we designed loss-of-function...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Wang, Runze, Xu, Yuerong, Niu, Xiaolin, Fang, Yexian, Guo, Dong, Chen, Jiangwei, Zhu, Hanzhao, Dong, Jiaying, Zhao, Ran, Wang, Ying, Qi, Bingchao, Ren, Gaotong, Li, Xue, Liu, Li, Zhang, Mingming
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8047466/
https://ncbi.nlm.nih.gov/pubmed/33868015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.646903
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