Inhibiting miR-22 Alleviates Cardiac Dysfunction by Regulating Sirt1 in Septic Cardiomyopathy

High morbidity and mortality are the most typical characteristics of septic cardiomyopathy. We aimed to reveal the role of miR-22 in septic cardiomyopathy and to explore the underlying mechanisms. miR-22 cardiac-specific knockout (miR-22(cKO)) mice and miR-22 cardiac-specific transgenic (miR-22(cOE)...

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Udgivet i:Front Cell Dev Biol
Main Authors: Wang, Runze, Xu, Yuerong, Zhang, Wei, Fang, Yexian, Yang, Tiqun, Zeng, Di, Wei, Ting, Liu, Jing, Zhou, Haijia, Li, Yan, Huang, Zhan-peng, Zhang, Mingming
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Cell and Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8047209/
https://ncbi.nlm.nih.gov/pubmed/33869205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.650666
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