Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer

Lung cancer is the leading cause of cancer deaths. Tumor heterogeneity, which hampers development of targeted therapies, was herein deconvoluted via single cell RNA sequencing in aggressive human adenocarcinomas (carrying Kras-mutations) and comparable murine model. We identified a tumor-specific, m...

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Publicado no:Commun Biol
Main Authors: Maroni, Giorgia, Bassal, Mahmoud A., Krishnan, Indira, Fhu, Chee Wai, Savova, Virginia, Zilionis, Rapolas, Maymi, Valerie A., Pandell, Nicole, Csizmadia, Eva, Zhang, Junyan, Storti, Barbara, Castaño, Julio, Panella, Riccardo, Li, Jia, Gustafson, Corinne E., Fox, Sam, Levy, Rachel D., Meyerovitz, Claire V., Tramontozzi, Peter J., Vermilya, Kimberly, De Rienzo, Assunta, Crucitta, Stefania, Bassères, Daniela S., Weetall, Marla, Branstrom, Art, Giorgetti, Alessandra, Ciampi, Raffaele, Del Re, Marzia, Danesi, Romano, Bizzarri, Ranieri, Yang, Henry, Kocher, Olivier, Klein, Allon M., Welner, Robert S., Bueno, Raphael, Magli, Maria Cristina, Clohessy, John G., Ali, Azhar, Tenen, Daniel G., Levantini, Elena
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8046784/
https://ncbi.nlm.nih.gov/pubmed/33854168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01897-6
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