Identification of a metabolic, transcriptomic and molecular signature of PNPLA3-mediated acceleration of steatohepatitis

BACKGROUND & AIMS: The mechanisms by which the I148M mutant variant of the patatin-like phospholipase domain-containing 3 (PNPLA3(I148M)) drives development of nonalcoholic steatohepatitis (NASH) is not known. The aim of this study was to obtain insights on mechanisms underlying PNPLA3(I148M) in...

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Publicado en:Hepatology
Main Authors: Banini, Bubu A, Kumar, Divya. P., Cazanave, Sophie, Seneshaw, Mulugeta, Mirshahi, Faridoddin, Santhekadur, Prasanna K., Wang, Liangsu, Guan, Hong Ping, Oseini, Abdul, Alonso, Cristina, Bedossa, Pierre, Koduru, Srinivas V., Min, Hae-Ki, Sanyal, Arun J.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8046714/
https://ncbi.nlm.nih.gov/pubmed/33131062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31609
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