Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer’s dementia

Transcriptome-wide association studies (TWAS) have been widely used to integrate transcriptomic and genetic data to study complex human diseases. Within a test dataset lacking transcriptomic data, traditional two-stage TWAS methods first impute gene expression by creating a weighted sum that aggrega...

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Bibliografiske detaljer
Udgivet i:PLoS Genet
Main Authors: Tang, Shizhen, Buchman, Aron S., De Jager, Philip L., Bennett, David A., Epstein, Michael P., Yang, Jingjing
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8046351/
https://ncbi.nlm.nih.gov/pubmed/33798195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009482
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