Bayesian Genome-wide TWAS Method to Leverage both cis- and trans-eQTL Information through Summary Statistics

Transcriptome-wide association studies (TWASs) have been widely used to integrate gene expression and genetic data for studying complex traits. Due to the computational burden, existing TWAS methods do not assess distant trans-expression quantitative trait loci (eQTL) that are known to explain impor...

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Detalhes bibliográficos
Publicado no:Am J Hum Genet
Main Authors: Luningham, Justin M., Chen, Junyu, Tang, Shizhen, De Jager, Philip L., Bennett, David A., Buchman, Aron S., Yang, Jingjing
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7536614/
https://ncbi.nlm.nih.gov/pubmed/32961112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2020.08.022
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