Single-Cell and Population Transcriptomics Reveal Pan-epithelial Remodeling in Type 2-High Asthma

The type 2 cytokine-high asthma endotype (T2H) is characterized by IL-13-driven mucus obstruction of the airways. To further investigate this incompletely understood pathobiology, we characterize IL-13 effects on human airway epithelial cell cultures using single-cell RNA sequencing, finding that IL...

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Publicado en:Cell Rep
Autores principales: Jackson, Nathan D., Everman, Jamie L., Chioccioli, Maurizio, Feriani, Luigi, Goldfarbmuren, Katherine C., Sajuthi, Satria P., Rios, Cydney L., Powell, Roger, Armstrong, Michael, Gomez, Joe, Michel, Cole, Eng, Celeste, Oh, Sam S., Rodriguez-Santana, Jose, Cicuta, Pietro, Reisdorph, Nichole, Burchard, Esteban G., Seibold, Max A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8046336/
https://ncbi.nlm.nih.gov/pubmed/32640237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107872
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