Enhanced differentiation of human induced pluripotent stem cells toward the midbrain dopaminergic neuron lineage through GLYPICAN‐4 downregulation

Enhancing the differentiation potential of human induced pluripotent stem cells (hiPSC) into disease‐relevant cell types is instrumental for their widespread application in medicine. Here, we show that hiPSCs downregulated for the signaling modulator GLYPICAN‐4 (GPC4) acquire a new biological state...

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Publicat a:Stem Cells Transl Med
Autors principals: Corti, Serena, Bonjean, Remi, Legier, Thomas, Rattier, Diane, Melon, Christophe, Salin, Pascal, Toso, Erik A., Kyba, Michael, Kerkerian‐Le Goff, Lydia, Maina, Flavio, Dono, Rosanna
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Inc. 2021
Matèries:
Pluripotent Stem Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8046045/
https://ncbi.nlm.nih.gov/pubmed/33528918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sctm.20-0177
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