Enhanced differentiation of human induced pluripotent stem cells toward the midbrain dopaminergic neuron lineage through GLYPICAN‐4 downregulation

Enhancing the differentiation potential of human induced pluripotent stem cells (hiPSC) into disease‐relevant cell types is instrumental for their widespread application in medicine. Here, we show that hiPSCs downregulated for the signaling modulator GLYPICAN‐4 (GPC4) acquire a new biological state...

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Detalles Bibliográficos
Publicado en:Stem Cells Transl Med
Main Authors: Corti, Serena, Bonjean, Remi, Legier, Thomas, Rattier, Diane, Melon, Christophe, Salin, Pascal, Toso, Erik A., Kyba, Michael, Kerkerian‐Le Goff, Lydia, Maina, Flavio, Dono, Rosanna
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley & Sons, Inc. 2021
Assuntos:
Pluripotent Stem Cells
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8046045/
https://ncbi.nlm.nih.gov/pubmed/33528918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sctm.20-0177
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