Pseurotin A as a Novel Suppressor of Hormone Dependent Breast Cancer Progression and Recurrence by Inhibiting PCSK9 Secretion and Interaction with LDL Receptor

Hypercholesterolemia has been documented to drive hormone-dependent breast cancer (BC) progression and resistance to hormonal therapy. Proprotein convertase subtilisin/kexin type-9 (PCSK9) regulates cholesterol metabolism through binding to LDL receptor (LDLR) and targeting the receptor for lysosoma...

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Publicado no:Pharmacol Res
Main Authors: Abdelwahed, Khaldoun S., Siddique, Abu Bakar, Mohyeldin, Mohamed M., Qusa, Mohammed H., Goda, Amira A., Singh, Sitanshu S., Ayoub, Nehad M., King, Judy Ann, Jois, Seetharama D., El Sayed, Khalid A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045554/
https://ncbi.nlm.nih.gov/pubmed/32438039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2020.104847
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